Daniel Vallera, PhD

Professor of Therapeutic Radiology-Radiation Oncology, Department of Radiation Oncology

Daniel Vallera

Contact Info

valle001@umn.edu

Office Phone 612-626-6664

Mobile Phone 612-546-8209

Office Address:
University of Minnesota Masonic Cancer Center,
Department of Radiation Oncology
Room 460B 425 E. River Road
Minneapolis, Minnesota 55455

Mailing Address:
Radiation Oncology, Dept of
MMC 494 Mayo
8494A (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

Professor of Therapeutic Radiology-Radiation Oncology, Department of Radiation Oncology

Lions Scholar of Molecular Therapeutics
Associate Professor of Therapeutic Radiology
Assistant Professor of Therapeutic Radiology
, Department of Radiation Oncology


Research Associate, University of Minnesota

Postdoctoral Fellow, University of Minnesota

PhD, Ohio State University (Microbiology), 1978

MS, Ohio State University (Microbiology), 1975

BS, Ohio State University (Microbiology), 1973

Summary

The goal of our laboratory is to advance the field of cancer by genetically engineering and testing new biological drugs against chemotherapy refractory cancer. These new drugs kill by a mechanism entirely different than chemotherapy. We believe that we are in a unique position to address some of the most pressing issues including the engagement of the innate immune system to kill cancer. A new genre of drugs show that cancer metastasis can effectively be combated by engaging the immune system to selectively kill tumors. We developed a new drug platform that works extremely well in recruiting NK cells to kill leukemia cells. In addition to my conventional laboratory, I am fortunate to have a cGMP laboratory that manufactures FDA compliant drugs for phase 1 testing. We published our first clinical trial with one of these drugs in Clinical Cancer Research. We have an accomplished team of experts that can help this integrated effort succeed. Our laboratory has an established track-record in animal models and I have a background in immunology, experimental therapeutics, molecular biology, radiation oncology, and gene therapy that has served us well. Over the last 35 years, I have built my career and reputation on cell selective drug targeting and am recognized as a major contributor to the field. My immunology and molecular biology background has served me well and my team has published over a hundred and eighty PubMed papers. Our success in translational research is evidenced by our bringing targeted drugs to phase 1 clinical trial. The most recent targeted toxin will now enter phase 2 testing. We currently have active INDs and are treating patients at the University of Minnesota Cancer Center. I have a demonstrated a record of successful and productive research projects in an area of translational, biological drug development and serve as inventor on several patents held by the University of Minnesota.

Expertise

Biologic Drug Development

Genetic Engineering

Immunotherapy

Radiation Biology Research

Bispecific Antibodies

Targeted Therapy

FDA Consultant

Awards & Recognition

Designated Lion Scholar-Lion Research Award

Randy Shaver Cancer Research Fund – 2016 Angel Award

Past Leukemia Society of America Scholar

Pierce Targeted Therapy Award

NIH REACH Award- 2016

Professional Associations

American Association of Immunologists

Transplantation Society

American Society of Hematology

Research

Research Funding Grants

NIH REACH (Research Evaluation and Commercialization Hub) Award (U01)

Minnesota Ovarian Cancer Alliance

NIH/NCI R01- (30 years)

Immunotoxins in bone marrow transplantation 1/1/1984—4/30/2016

Lion Drug Development Foundation

William Lawrence-Blanches Hughes Foundation

University of Minnesota, Office of Technology, Committee on Pharmaceutical Development Award

Randy Shaver Foundation

Special Radiation Oncology Project Development Award

Publications

  • 1.Vallera DA, Felices M, McElmurry R, McCullar V, Zhou X, Schmohl J, Zhang B, Lenvik A, Panoskaltsis-Mortari A, Verneris MR, Tolar J, Cooley S, Weisdorf DJ, Blazar BR, Miller JS. IL-15 Trispecific Killer Engagers (TriKEs) Make NK Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function. Clin Cancer Res. 2016. In Press.
  • This paper selected as 2016 Editors Choice by the Journal Science Translational Medicine. Roxana Dronca, Turning BiKEs into TriKEs to fight cancer. Science Translational Medicine 2016 8:328
  • 2.Schmohl JU, Vallera DA. CD133, Selectively Targeting the Root of Cancer. Toxins (Basel). 2016 May 28;8(6). pii: E165.
  • 3.Felices M, Lenvik TR, Davis ZB, Miller JS, Vallera DA. Generation of BiKEs and TriKEs to improve NK Cell-Mediated Targeting of Tumor Cells. Methods Mol Biol. 2016;1441:333-46.
  • 4.Schmohl JU, Felices M, Taras E, Miller JS, Vallera DA. Enhanced ADCC and NK Cell Activation of an Anticarcinoma Bispecific Antibody by Genetic Insertion of a Modified IL-15 Cross-linker. Mol Ther. 2016 Aug;24(7):1312-22.
  • 5.Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick E, Kantarjian H, Weisdord DD, Miller JS, Vallera DA. Phase 1 study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies. Clin Cancer Res. 2015;21:1267-72.
  • 6.Schmohl JU, Gleason MK, Dougherty PR, Miller JS, Vallera DA. Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells. Target Oncol. 2015. In Press. PMID: 26566946
  • 7.Schmohl JU, Todhunter D, Oh S, Vallera DA. Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development. Toxins (Basel). 2015 Oct 10;7:4067-82. PMID: 26473923
  • 8.Huang J, Li YM, Cheng Q, Vallera DA, Hall WA.A novel brain metastasis xenograft model for convection?enhanced delivery of targeted toxins via a micro?osmotic pump system enabled for real?time bioluminescence imaging. Mol Med Rep. 2015 Oct;12:5163-8 PMID: 26238362
  • 9.Shen J, Vallera DA, Wagner CR. Prosthetic Antigen Receptors. J Am Chem Soc. 2015 Aug 19;137:10108-11. PMID: 26230248
  • 10.Waldron NN, Barsky SH, Dougherty PR, Vallera DA. A bispecific EpCAM/CD133-targeted toxin is effective against carcinoma. Target Oncol. 2014 Sep;9:239-49. PMID: 23900680
  • 11.Gleason MK, Ross JA, Warlick ED, Lund TC, Verneris MR, Wiernik A, Spellman S, Haagenson MD, Lenvik AJ, Litzow MR, Epling-Burnette PK, Blazar BR, Weiner LM, Weisdorf DJ, Vallera DA, Miller JS. CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets. Blood. 2014 May 8;123(19):3016-26. PMID: 24652987
  • 12.Gleason MK, Ross JA, Warlick ED, Lund TC, Verneris MR, Wiernik A, Spellman S, Haagenson MD, Lenvik AJ, Litzow MR, Epling-Burnette PK, Blazar BR, Weiner LM, Weisdorf DJ, Vallera DA, Miller JS. CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells from MDS patients against primary MDS and MDSC CD33+ targets. Blood. 2014 Mar 20. [Epub ahead of print] PMID: 24652987. PMCID: PMC4014844