Research

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Research focus areas:

Faculty lab highlights

The molecular basis of addiction

The Lee Lab uses a multi-disciplinary approach to study how regulation of nicotinic acetylcholine receptors affects neuronal function and behavior in mouse models of addiction and affective disorders.

Mechanisms disrupted in cancer

The Levinson Lab studies how protein-protein interactions induce conformational changes at a distance, a phenomenon termed allostery. Allosteric regulation mechanisms that tightly control protein function are widespread in biology, and their disruption is often linked to disease.

Cells in the immune system

The Freedman Lab aims to understand macrophage and lymphocyte signaling with the goal of undertanding how inflammation and dysregulation can affect cell sensitivity and exacerbate disease, how protein-protein interactions at the plasma membrane regulate signaling, and how receptor clustering enables signaling. 

Dysregulation of cell excitability

The Wickman Laboratory seeks to better understand molecules and mechanisms that control excitability, so that safer and more effective strategies can be developed to treat afflictions such as cardiac arrhythmias, epilepsy, anxiety, depression, schizophrenia, Down Syndrome, addiction, and pain.